BARGE member profile — Dr Mark Cave

Dr Mark Cave
BARGE Chairman

British Geological Survey
Kingsley Dunham Centre
NG12 5GG
United Kingdom



Pelfrêne, A, Cave, M R, Wragg, J and Douay, F.  2017.  In Vitro Investigations of Human Bioaccessibility from Reference Materials Using Simulated Lung Fluids. International Journal of Environmental Research and Public Health 2017, 14(2), 112.

McIlwaine, R, Doherty, R, Cox, S F, and Cave, M.  2017.  The relationship between historical development and potentially toxic element concentrations in urban soils. Volume 220, 1036–1049.


Beriro, D J, Cave, M, Wragg, J, Thomas, R, Wills, G, and Evans, F.  2016.  A review of the current state of the art of physiologically based tests for measuring human dermal in vitro bioavailability of polycyclic aromatic hydrocarbons (PAH) in soil.  Journal of Hazardous Materials, 305, 240–259.

Cave, M R, Rosende, M, Mountenay, I, Gardner, A and Miro, M.  2016.  New Insights into the Reliability of Automatic Dynamic Methods for Oral Bioaccessibility Testing: A Case Study for BGS102 soil. Environmental Science & Technology, 50(17), 9479–9486. Published: SEP 6 2016.

James, K, Peters, R E, Cave, M R, Wickstrom, M, Lamb, E G, and Siciliano, S D.  2016.  Predicting polycyclic aromatic hydrocarbon bioavailability to mammals from incidentally ingested soils using partitioning and fugacity.  Environmental Science & Technology, 50, 1338–1346.

Marinho–Reis, A P, Shepherd T, Nowell, G, Cachada, A, Costa Duarte, A, Cave, M, Wragg, J, Patinha, C, Dias, A, Rocha, F, Ferreira da Silva, E, Sousa, A J, Prazes, C and Batista, M J.  2016.  Source and pathway analysis of lead and polycyclic aromatic hydrocarbons in Lisbon urban soils. Science of The Total Environmen, 573, 324–336.

Peters, R E, and James, K.  2016.  Is received dose from ingested soil independent of soil PAH concentrations?—Animal model results. Environmental Toxicology and Chemistry, 35(9), 2261–2269.


Cave, M R, Vane, C H, Kim, A, Moss-Hayes, V L, Wragg, J, Richardson, C, Harrison, H, Nathanail, C P, Thomas, T, and Wills, G.  2015.  Measurement and modelling of the ingestion bioaccessibility of polyaromatic hydrocarbons in soils.  Environmental Technology & Innovation, 3, 35–45.

Cave, M, Wragg, J, Gowing, C, and Gardner, A.  2015.  Measuring the solid-phase fractionation of lead in urban and rural soils using a combination of geochemical survey data and chemical extractions.  Environmental Geochemistry and Health, 37, 779–790.

Li, J, Li, K, Cave, M, Li, H-B, and Ma, L Q.  2015.  Lead bioaccessibility in 12 contaminated soils from China: correlation to lead relative bioavailability and lead in different fractions.  Journal of Hazardous Materials, 295, 55–62.

Palmer, S, McIlwaine, R, Ofterdinger, U, Cox, S F, McKinley, J M, Doherty, R, Wragg, J, and Cave, M.  2015.  The effects of lead sources on oral bioaccessibility in soil and implications for contaminated land risk management.  Environmental Pollution, 198, 161–171.

Palumbo-Roe, B, Wragg, J, and Cave, M.  2015.  Linking selective chemical extraction of iron oxyhydroxides to arsenic bioaccessibility in soil.  Environmental Pollution, 207, 256–265.

Patinha, C, Reis, A P, Dias, A C, Abduljelil, A A, Noack, Y, Robert, S, Cave, M, and Ferreira da Silva, E.  2015.  The mobility and human oral bioaccessibility of Zn and Pb in urban dusts of Estarreja (N Portugal).  Environmental Geochemistry and Health, 37, 115–131.

Reis, A P, Costa, S, Santos, I, Patinha, C, Noack, Y, Wragg, J, Cave, M, and Sousa, A J.  2015.  Investigating relationships between biomarkers of exposure and environmental copper and manganese levels in house dusts from a Portuguese industrial city.  Environmental Geochemistry and Health, 37, 725–744.


Beriro, D J, Vane, C H, Cave, M R, and Nathanail, C P.  2014.  Effects of drying and comminution type on the quantification of polycyclic aromatic hydrocarbons (PAH) in a homogenised gasworks soil and the implications for human health risk assessment.  Chemosphere, 111, 396–404.

Reis, A P, Patinha, C, Wragg, J, Dias, A C, Cave, M, Sousa, A J, Batista, M J, Prazeres, C, Costa, C, Ferreira da Silva, E, and Rocha, F.  2014.  Urban geochemistry of lead in gardens, playgrounds and schoolyards of Lisbon, Portugal: assessing exposure and risk to human health.  Applied Geochemistry, 44, 45–53.

Reis, A P, Patinha, C, Wragg, J, Dias, A C, Cave, M, Sousa, A J, Costa, C, Cachada, A, Ferreira da Silva, E, Rocha, F, and Duarte, A.  2014.  Geochemistry, mineralogy, solid-phase fractionation and oral bioaccessibility of lead in urban soils of Lisbon.  Environmental Geochemistry and Health, 36, 867–881.

Wragg, J, Cave, M, and Gregory, G.  2014.  The solid-phase distribution and bioaccessibility of arsenic, chromium, and nickel in natural ironstone soils in the UK , Applied and Environmental Soil Science


Appleton, J D, Cave, M R, Palumbo-Roe, B, and Wragg, J.  2013.  Lead bioaccessibility in topsoils from lead mineralisation and urban domains, UK.  Environmental Pollution, 178, 278–287.

Cave, M R, Wragg, J, and Harrison, H.  2013.  Measurement modelling and mapping of arsenic bioaccessibility in Northampton, United Kingdom.  Journal of Environmental Science and Health, Part A, 48, 629–640.

Cox, S F, Chelliah, M C M, McKinley, J M, Palmer, S, Ofterdinger, U, Young, M E, Cave, M R, and Wragg, J.  2013.  The importance of solid-phase distribution on the oral bioaccessibility of Ni and Cr in soils overlying Palaeogene basalt lavas, Northern Ireland.  Environmental Geochemistry and Health, 35, 553–567.

Koch, I, Reimer, K J, Bakker, M I, Basta, N T, Cave, M R, Denys, S, Dodd, M, Hale, B A, Irwin, R, Lowney, Y W, Moore, M M, Paquin, V, Rasmussen, P E, Repaso-Subang, T, Stephenson, G L, Siciliano, S D, Wragg, J, and Zagury G J.  2013.  Variability of bioaccessibility results using seventeen different methods on a standard reference material, NIST 2710.  Journal of Environmental Science and Health, Part A, 48, 641–655.

Palumbo-Roe, B, Wragg, J, Cave, M R, and Wagner, D.  2013.   Effect of weathering product assemblages on Pb bioaccessibility in mine waste: implications for risk management.  Environmental Science and Pollution Research, 20, 7699–7710.


Appleton J D, Cave, M R, and Wragg, J.  2012.  Anthropogenic and geogenic impacts on arsenic bioaccessibility in UK topsoils.  Science of The Total Environment, 435–436, 21–29.

Appleton J D, Cave, M R, and Wragg, J.  2012.  Modelling lead bioaccessibility in urban topsoils based on data from Glasgow, London, Northampton and Swansea, UK .  Environmental Pollution, 171, 265–272

Barsby, A, McKinley, J M, Ofterdinger, U, Young, M, Cave, M R, and Wragg, J.  2012.  Bioaccessibility of trace elements in soils in Northern Ireland.  Science of The Total Environment, 433, 398–417.

Denys, S, Caboche, J, Tack, K, Rychen, G, Wragg, J, Cave, M, Jondreville, C, and Feidt, C.  2012 In vivo validation of the unified BARGE method to assess the bioaccessibility of arsenic, antimony, cadmium and lead in soils.  Environmental Science & Technology, 46, 6252–6260

Lorenzi, D, Entwistle, J, Cave, M, Wragg, J, and Dean, J R.  2012.   The application of an in vitro gastrointestinal extraction to assess the oral bioaccessibility of polycyclic aromatic hydrocarbons in soils from a former industrial site.  Analytica Chimica Acta, 735, 54–61.

Wragg, J, and Cave, M.  2012.  Assessment of a geochemical extraction procedure to determine the solid-phase fractionation and bioaccessibility of potentially harmful elements in soils: a case study using the NIST 2710 reference soil.  Analytica Chimica Acta, 722, 43–54.


Cave, M R, Wragg, J, Denys, S, Jondreville, C, and Feidt, C.  2011.  Oral bioavailability. In Dealing with Contaminated Sites.  Swartjes, F (editor).

Farmer, J G, Broadway, A, Cave, M R, Wragg, J, Fordyce, F M, Graham, M C, Ngwenya, B T, and Bewley, R J F.  2011.  A lead isotopic study of the human bioaccessibility of lead in urban soils from Glasgow, Scotland.  Science of The Total Environment, 409, 4958–4965.

Wragg, J, Cave, M, Basta, N, Brandon, E, Casteel, S, Denys, S, Grøn, C, Oomen, A, Reimer, K, Tack, K, and Van de Wiele, T.  2011.  An inter-laboratory trial of the unified BARGE bioaccessibility method for arsenic, cadmium and lead in soil.  Science of The Total Environment, 409, 4016–4030


Cave, M R, Wragg, J, Harrison, I, and Vane, C H.  2010.  Comparison of batch mode and dynamic physiologically based bioaccessibility tests for PAHs in soil samples.  Environmental Science & Technology, 2654–2660


Cave, M, Palumbo-Roe, B, Klinck, B, and Wragg, J.  2008.  A lines of evidence approach to the assessment of the bioaccessibility as in soils in the UK.  Epidemiology, 19, S1–S12.


Cave, M, Taylor, H, and Wragg, J.  2007.  Estimation of the bioaccessible arsenic fraction in soils using near infrared spectroscopy.  Journal of Environmental Science and Health, Part A, 42, 1293–1301

Van de Wiele, T R, Oomen, A G, Wragg, J, Cave, M, Minekus, M, Hack, A, Cornelis, C, Rompelberg, C J M, De Zwart, L L, Klinck, B, Van Wijnen, J, Verstraete, W, and Sips, A J A M.  2007.  Comparison of five in vitro digestion models to in vivo experimental results: lead bioaccessibility in the human gastrointestinal tract.  Journal of Environmental Science and Health, Part A, 42, 1203–1211

Wragg, J, Cave, M, and Nathanail, P.  2007.  A study of the relationship between arsenic bioaccessibility and its solid-phase distribution in soils from Wellingborough, UK.  Journal of Environmental Science and Health, 42, 1303–1315


Cave, M, Wragg, J, Klinck, B, Grøn, C, Oomen, A, van de Wiele, T, Ollson, C, Koch, I, Reimer, K, Basta, N, and Tack, K.  2006.  Preliminary assessment of a unified bioaccessibility method for potentially harmful elements in soils.  Epidemiology, 17, S39


Palumbo-Roe, B, Cave, M R, Klinck, B A, Wragg, J, Taylor, H, '’Donnell, K E, and Shaw, R A.  2005.  Bioaccessibility of arsenic in soils developed over Jurassic ironstones in eastern England.  Environmental Geochemistry and Health, 27, 121–130